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Tissue Specific Response to Burn Injury



Introduction

Patients with severe burn injury tend to have marked hyper-metabolism and catabolism, which are associated with morbidity and mortality. The common symptoms during the recovery of burn injury are

    •Insulin resistance and hyperglycemia
    •Skeletal muscle proteolysis
    •Adipose tissue lipolysis

To investigate the underlying mechanism of these symptoms after burn injury, more than 200 patient samples from each of four tissue types, including fat, muscle, skin and blood, were collected and processed by a large-scale Collaboration funded by NIGMS, the Glue Grant "Inflammation and Host Response Injury", to study genomic responses in human to burn injury.

The number of samples processed with Affymetrix U133 plus v2 GeneChip microarrays (including more than 54,000 probe sets corresponding to ~25,000 genes in human) for each tissue type is listed in the table below.

Fat Muscle Skin Blood
Patient 195 210 206 598
Control45 344298
Total240 244248696



Navigations

Descriptions of the data, analysis methods, and glossary
Expression change pattern and information of individual genes across tissue types.
• Clustered gene expression patterns and pathway analysis after burn injury for each tissue type.
   o Fat
   o Muscle
   o Skin
   o Blood

Disclaimers

The website is a tool to explore the clinical and genomic dataset contained in the original publication, using intuitive and friendly tools. This website is copyrighted and is the property of Massachusetts General Hospital. The Glossary and Methods contains a detailed explanation of the statistical and bioinformatics approaches used in the website, as well as definitions. The data employs statistical approaches and software tools that were current as of 10 November 2009, but may have been superceded. Some links to external sites may require prior registration.

Unrestricted access to the dataset, including individual expression values, requires consortium membership and IRB approval from your local institution.

For detailed instructions, follow the links at www.gluegrant.org.