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Transcriptome Changes in Skin Tissue



The average variation pattern of gene expression in Skin tissue over time after burn injuries is shown in the heatmap below. Each row of the heatmap shows the average expression level of one significant gene over the time. The left-most column shows the control level, which serves as a reference. The rest columns are the average expression levels among all the burned patients over 5 time bins, 0-4 days, 4-10 days, 10-21 days, 21-60 days and after 60 days, respectively.

7121 genes (11759 probesets) differentially expressed between patients and controls are grouped into 6 clusters by K-mean clustering algorithm. Among these significant genes, 3606 genes (5530 probesets) are up-regulated and 3552 genes (6229 probesets) are down-regulated.

Note: To see the detailed information of a cluster, click the cluster on the heatmap below.

Clustering

To see the detail information of a cluster, click the cluster on the heatmap below.




Pathway analysis of significant genes in Skin tissue

Most significant 15 pathways by Ingenuity



Ingenuity Canonical Pathway p-value(log) Ratio Molecules
Hepatic Fibrosis / Hepatic Stellate Cell Activation12.80.639ACTA2, AGT, AGTR1, BAX, BCL2, CCL2, CCL5, CD14, COL1A2, COL3A1, CSF1, CTGF, CXCL3, CYP2E1, EDNRA, EDNRB, EGF, EGFR, FAS, FGF1, FGF2, FGFR1, FGFR2, FIGF, FLT1, FN1, HGF, ICAM1, IFNAR2, IGF1, IGF1R, IGFBP3, IGFBP5, IL6, IL8, IL10, IL10RA, IL18RAP, IL1A, IL1B, IL1R1, IL1RL1, IL1RL2, IL4R, IL6R, KDR, LBP, LEP, LEPR, LY96, MET, MMP2, MMP1 (includes EG:43, MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH8, MYH9, MYH10, MYH11, MYH14, MYH7B (includes EG:5, MYL1, MYL2, MYL3, MYL4, MYL6B, MYL9 (includes EG:10, PDGFA, PDGFC, PDGFRA, PDGFRB, PGF, SERPINB2, SMAD4, STAT1, TGFA, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TIMP2, TLR4, TNFRSF11B, TNFRSF1B, VCAM1, VEGFA, VEGFC
Molecular Mechanisms of Cancer100.48ADCY2, ADCY4, ADCY9, AKT2, AKT3, APH1A (includes EG:5, APH1B, ARHGEF1, ARHGEF2, ARHGEF4, ARHGEF5, ARHGEF6, ARHGEF7, ARHGEF12, ARHGEF18, ARHGEF19, ATM, AURKA, BAD, BAK1, BAX, BCL2, BID, BMP1, BMP2, BMP5, BMP6, BMP7, BMPR2, BMPR1A, BRAF, CAMK2B, CAMK2D, CASP3, CBL, CCND1, CCNE1, CCNE2, CDC42, CDC25A, CDC25B, CDH1, CDK2, CDK6, CDKN1A, CDKN1B, CDKN2B, CDKN2C, CFLAR, CHEK1, CTNND1, CYCS (includes EG:54, E2F2, E2F3, FANCD2, FAS, FOS, FOXO1, FYN, FZD4, FZD6, FZD7, FZD8, FZD10, GAB1, GNA12, GNA13, GNA14, GNA15, GNAI1, GNAI2, GNAI3, GNAL, GNAQ, GNAS, HAT1, HHAT, HIPK2, HRAS, IRS1, JAK1, JAK2, LEF1, LRP5, LRP6, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K7, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAPK12, MAPK13, MAX, MDM2, MRAS, NAIP, NBN, NFKBIA, NFKBIB, NLK, NOTCH1, PA2G4, PAK2, PAK4, PAK6, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCB1, PLCB3, PLCB4, PMAIP1, PRKACB, PRKAR1A, PRKAR2B, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, PSEN1, PTK2, PTPN11, RABIF, RAC2, RALB, RALBP1, RALGDS, RAP1A, RAP2A, RAPGEF3, RASGRF2, RASGRP1, RB1, RBPJ, RHOC, RHOD, RHOF, RHOJ, RHOQ, RHOU, RHOV, RRAS2, SIN3A, SMAD1, SMAD4, SMAD6, SMAD9, SOS1, SOS2, SRC, SUFU, SUV39H1, SYNGAP1, TCF3, TCF4, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TP53, WNT5A
HER-2 Signaling in Breast Cancer9.270.675AKT3, AREG, ATM, BAD, CCND1, CCNE1, CCNE2, CDC42, CDK6, CDKN1A, CDKN1B, EGF, EGFR, ERBB2, ERBB3, FOXO1, HRAS, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB8, MDM2, MMP2, MRAS, NRG1, PARD3, PARD6B, PARD6G, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RAC2, RRAS2, SOS1, SOS2, TP53, TSC2
HGF Signaling8.980.626AKT3, ATF2, ATM, CCND1, CDC42, CDK2, CDKN1A, DOCK1, ELF1, ELF2, ELF3, ELF4, ELF5, ELK3, ETS1, ETS2, FOS, GAB1, HGF, HRAS, IL6, MAP2K1, MAP2K2, MAP2K7, MAP3K1, MAP3K2, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP3K11, MAP3K13, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAPK12, MET, MRAS, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, PTK2, PTPN11, RAC2, RAP1A, RRAS2, SOS1, SOS2, STAT3
Axonal Guidance Signaling8.820.466ABLIM2, ABLIM3, ADAM9, ADAM10, ADAM12, ADAM15, AKT2, AKT3, ARHGEF6, ARHGEF7, ARHGEF12, ARPC4, ARPC1A, ARPC5L (includes EG:, ATM, BAIAP2, BDNF, BMP1, BMP2, BMP5, BMP6, BMP7, CDC42, CDK5, CFL1, CFL2, CXCL12, CXCR4, DOCK1, DPYSL2, EFNA1, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EGF, EIF4E, EPHA1, EPHA2, EPHA3, EPHA4, EPHB3, EPHB4, EPHB6, ERBB2, FIGF, FYN, FZD4, FZD6, FZD7, FZD8, FZD10, GLI3, GLIS2, GNA12, GNA13, GNA14, GNA15, GNAI1, GNAI2, GNAI3, GNAL, GNAQ, GNAS, GNB2, GNB4, GNB5, GNB1L, GNG2, GNG4, GNG10, GNG11, GNG12, HRAS, IGF1, ITGA2, ITGA3, ITGA4, ITGB1, ITSN1, KLK1, L1CAM, LIMK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MRAS, MYL1, MYL2, MYL3, MYL4, MYL12A, MYL6B, MYL9 (includes EG:10, MYLPF, NFAT5, NFATC2, NGEF, NRP1, NTRK2, PAK2, PAK4, PAK6, PDGFA, PDGFC, PDGFD, PFN1, PFN2, PGF, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCB1, PLCB3, PLCB4, PLXNA2, PLXNB1, PLXNB2, PLXNC1, PLXND1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PRKACB, PRKAR1A, PRKAR2B, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, PTK2, PTPN11, RAC2, RAP1A, RASSF5, RGS3, RHOD, ROBO1, ROBO2, ROCK1, ROCK2, RRAS2, RTN4R, SDC2, SDCBP, SEMA3C, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4G, SEMA6D, SEMA7A, SLIT2, SLIT3, SOS1, SOS2, SRGAP1, SRGAP2, SUFU, UNC5B, VEGFA, VEGFC, WASL (includes EG:89, WIPF1, WNT3, WNT4, WNT16, WNT10A, WNT2B, WNT5A, WNT5B, WNT7B
CXCR4 Signaling8.250.538ADCY2, ADCY4, ADCY9, AKT2, AKT3, ATM, CXCL12, CXCR4, DOCK1, EGR1, ELMO1, ELMO3, FOS, GNA12, GNA13, GNA14, GNA15, GNAI1, GNAI2, GNAI3, GNAL, GNAQ, GNAS, GNB2, GNB4, GNB5, GNB1L, GNG2, GNG4, GNG10, GNG11, GNG12, HRAS, ITPR1, ITPR2, ITPR3, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAPK12, MRAS, MYL1, MYL2, MYL3, MYL4, MYL12A, MYL6B, MYL9 (includes EG:10, MYLPF, PAK2, PAK4, PAK6, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCB1, PLCB3, PLCB4, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, PTK2, RAC2, RHOC, RHOD, RHOF, RHOJ, RHOQ, RHOU, RHOV, ROCK1, ROCK2, RRAS2, SRC
Pancreatic Adenocarcinoma Signaling8.180.57AKT3, ATM, BAD, BCL2, BIRC5, CCND1, CCNE1, CDC42, CDK2, CDKN1A, CDKN1B, CDKN2B, CYP2E1, E2F2, E2F3, EGF, EGFR, ERBB2, FIGF, GPLD1, HBEGF, JAK1, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAPK12, MDM2, NOTCH1, PA2G4, PDGFC, PGF, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLD1, PLD2, PLD3, RAC2, RAD51, RALBP1, RALGDS, RB1, SIN3A, SMAD4, STAT1, STAT3, SUV39H1, TFDP1, TGFA, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TP53, VEGFA, VEGFC
IL-8 Signaling8.050.518AKT3, ANGPT1, ANGPT2, ATM, BAX, BCL2, BRAF, CCND1, CDH1, CSTB, CXCL1, CXCR2, CYBB, EGF, EGFR, FIGF, FLT1, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAS, GNB2, GNB4, GNB5, GNB1L, GNG2, GNG4, GNG10, GNG11, GNG12, GPLD1, HBEGF, HRAS, ICAM1, IL8, IRAK3, ITGAM, ITGB2, KDR, LIMK2, MAP2K1, MAP2K2, MAP4K4, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAPK12, MMP2, MRAS, MYL2, NFKBIB, NOX4, PAK2, PDGFC, PGF, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLD1, PLD2, PLD3, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, PTK2, PTK2B, RAC2, RHOC, RHOD, RHOF, RHOJ, RHOQ, RHOU, RHOV, ROCK1, ROCK2, RPS6KB1, RRAS2, SRC, TEK, VCAM1, VEGFA, VEGFC
Nicotinate and Nicotinamide Metabolism7.680.471AKT2, AOX1, BRAF, BST1, CD38, CDK1, CDK2, CDK5, CDK6, CDK7, CDK8, CILP, CSNK1A1, DAPK1, DUSP16, DUSP18, EIF2AK2, ENPP1, ENPP2, ENPP5, ENTPD3, GRK5, GRK6, LIMK2, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K6, MAP3K8, MAP3K9, MAPK1, MAPK3, MAPK6, MAPK7, MAPK8, MAPK9, NADSYN1, NAMPT, NAPRT1, NEK2, NMNAT3 (includes EG:, NNMT, NNT, NT5E, NUDT12, PAK2, PIM1, PLK1, PNP, PRKAA1, PRKAA2, PRKCD, PRKCE, PRKCH, PRKCQ, PRKX, PRPF4B, SGK1, TTK, VNN1, VNN2, VNN3
Actin Cytoskeleton Signaling7.540.492ACTA2, ACTC1, ACTG2 (includes EG:7, ACTN2, ACTN3, ACTN4, ARHGEF1, ARHGEF4, ARHGEF6, ARHGEF7, ARHGEF12, ARPC4, ARPC1A, ARPC5L (includes EG:, ATM, BAIAP2, CD14, CDC42, CFL1, CFL2, CSK, CYFIP2 (includes EG:, DIAPH3, DOCK1, EGF, EZR, F2R, FGD1, FGF1, FGF2, FGF7, FGF11, FGF13, FN1, GNA12, GNA13, GNG12, HRAS, IQGAP1, IQGAP2, IQGAP3, ITGA2, ITGA3, ITGA4, ITGB1, LBP, LIMK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MRAS, MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH8, MYH9, MYH10, MYH11, MYH14, MYH7B (includes EG:5, MYL1, MYL2, MYL3, MYL4, MYL12A, MYL6B, MYL9 (includes EG:10, MYLK, MYLK2, MYLK3, MYLPF, NCKAP1L, PAK2, PAK4, PAK6, PDGFA, PDGFC, PDGFD, PFN1, PFN2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIKFYVE, PIP4K2A, PIP4K2C, PIP5K1B, PPP1CA, PPP1CB, PPP1R12A, PPP1R12B, PTK2, RAC2, RDX, ROCK1, ROCK2, RRAS2, SOS1, SOS2, SSH2, SSH3, TIAM1, TTN, VAV3, WASF2, WASL (includes EG:89
Role of Tissue Factor in Cancer7.470.595AKT3, ATM, CASP3, CDC42, CFL1, CFL2, CSF1, CTGF, CXCL1, EGFR, EGR1, EIF4E, F3, F2RL1, FGR, FYN, GNA12, GNA13, GNA14, GNAQ, HBEGF, HCK, HRAS, IL8, IL1B, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, JAK2, LIMK2, LYN, MAPK1, MAPK3, MAPK12, MAPK13, MMP1 (includes EG:43, MRAS, P4HB, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLAUR, PLCB1, PRKCA, PTEN, PTK2B, PTPN11, RAC2, RPS6KA1, RPS6KA3, RPS6KA4, RPS6KA6, RPS6KB1, RRAS2, SRC, STAT5A, STAT5B, TP53, VEGFA, VEGFC
RhoA Signaling7.450.609ACTA2, ACTC1, ACTG2 (includes EG:7, ANLN, ARHGAP6, ARHGAP8, ARHGAP9, ARHGAP12, ARHGEF1, ARHGEF12, ARPC4, ARPC1A, ARPC5L (includes EG:, BAIAP2, CDC42EP1, CDC42EP3, CDC42EP5, CFL1, CFL2, CIT, DLC1, EPHA1, EZR, GNA12, GNA13, IGF1, IGF1R, KTN1, LIMK2, LPAR1, LPAR2, LPAR3, MYL1, MYL2, MYL3, MYL4, MYL12A, MYL6B, MYL9 (includes EG:10, MYLK, MYLK2, MYLK3, MYLPF, NGEF, PFN1, PFN2, PIKFYVE, PIP4K2A, PIP4K2C, PIP5K1B, PLD1, PPP1R12A, PPP1R12B, PTK2, PTK2B, RAPGEF2, RDX, ROCK1, ROCK2, RTKN, 2-Sep, 4-Sep, 5-Sep, 6-Sep, 8-Sep, TTN
Growth Hormone Signaling7.330.627ATM, CEBPA, FOS, GHR, IGF1, IGF2, IGF1R, IGFBP3, IRS1, JAK2, MAPK1, MAPK3, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RPS6KA1, RPS6KA3, RPS6KA4, RPS6KA6, RPS6KB1, RPS6KB2, SLC2A4, SOCS2, SOCS4, SOCS5, SOCS6, SOCS7, STAT1, STAT3, STAT5A, STAT5B
Role of NFAT in Cardiac Hypertrophy7.270.488ADCY2, ADCY4, ADCY9, AKT2, AKT3, ATM, CALM1, CALML5, CAMK1D, CAMK2B, CAMK2D, CSNK1A1, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GNB2, GNB4, GNB5, GNB1L, GNG2, GNG4, GNG10, GNG11, GNG12, HDAC1, HDAC5, HDAC11, HDAC9 (includes EG:9, HRAS, IGF1, IGF1R, IL6, IL6ST, ITPR1, ITPR2, ITPR3, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, MAP3K1, MAP3K7, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAPK12, MAPK13, MEF2A (includes EG:4, MEF2C, MRAS, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCB1, PLCB3, PLCB4, PLCD1, PLCD4, PLCE1, PLCH2, PLCL1, PLCL2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PRKACB, PRKAR1A, PRKAR2B, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RAC2, RCAN2, RCAN3, RRAS2, SLC8A3, SOS1, SOS2, SRC, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis7.190.494ACTA2, ACTC1, ACTG2 (includes EG:7, AP1B1, AP1G2, AP2A1, AP2B1, AP2S1, ATM, CAV1, CD55, CDC42, CLTB, CLTCL1, CXADR, DNM1, DNM2, FLNA, FLNB, FLNC, FYN, HLA-B, HRAS, ITGA2, ITGA3, ITGA4, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB8, ITSN1, MRAS, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKCA, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RAC2, RRAS2, SRC, TFRC