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Transcriptome Changes in Blood Tissue



The average variation pattern of gene expression in Blood tissue over time after burn injuries is shown in the heatmap below. Each row of the heatmap shows the average expression level of one significant gene over the time. The left-most column shows the control level, which serves as a reference. The rest columns are the average expression levels among all the burned patients over 5 time bins, 0-4 days, 4-10 days, 10-21 days, 21-60 days and after 60 days, respectively.

5914 genes (10368 probesets) differentially expressed between patients and controls are grouped into 6 clusters by K-mean clustering algorithm. Among these significant genes, 1872 genes (3245 probesets) are up-regulated and 4074 genes (7123 probesets) are down-regulated.

Note: To see the detailed information of a cluster, click the cluster on the heatmap below.

Clustering

To see the detail information of a cluster, click the cluster on the heatmap below.




Pathway analysis of significant genes in Blood tissue

Most significant 15 pathways by Ingenuity



Ingenuity Canonical Pathway p-value(log) Ratio Molecules
Role of NFAT in Regulation of the Immune Response9.220.443AKT2, AKT3, ATM, BLNK, CABIN1, CALM1, CAMK4, CD4, CD28, CD86, CD247, CD3D, CD3E, CD3G, CD79A, CD79B, CHP, CSNK1A1, CSNK1D, CSNK1G2, FCER1A, FCER1G, FCGR1A, FCGR1B, FCGR2B, FCGR2C, FCGR3B, FYN, GNA13, GNA15, GNAI3, GNAQ, GNAS, GNB2L1, GNG2, GNG5, GNG7, GNG11, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IKBKAP, IKBKB, ITK, ITPR1, ITPR3, KRAS, LCK, LCP2, MAPK1, MEF2A (includes EG:4, MEF2C, MEF2D, MS4A2, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKB2, NFKBIE, NRAS, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCB1, PLCG1, PPP3CC, PRKCQ, RAC1, RAC2, RAF1, RCAN3, RRAS2, SOS1, SOS2, TRA@, TRD@, XPO1, ZAP70
T Cell Receptor Signaling8.20.509BMX, CALM1, CAMK4, CARD11, CBL, CD4, CD28, CD247, CD3D, CD3E, CD3G, CD8A, CD8B, CTLA4, FYN, GRAP2, IKBKB, ITK, KRAS, LCK, LCP2, MALT1, MAPK1, MAPK8, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKB2, NRAS, PAG1, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCG1, PPP3CC, PRKCQ, RAC1, RAF1, RASA1, RASGRP1, RRAS2, SOS1, SOS2, TRA@, TXK, VAV2, VAV3, ZAP70
iCOS-iCOSL Signaling in T Helper Cells7.890.48CAMK2D, CAMK2G, CARD11, CD4, CD28, CD86, CD247, CD3D, CD3E, CD3G, CHP, FCER1G, FYN, GRAP2, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IKBKB, KRAS, LCK, LCP2, MALT1, MAP3K2, MAP3K4, MAP3K8, MAP3K14, MAPK1, MAPK8, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKB2, NFKBIE, NRAS, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCG1, PPP3CC, PRKCQ, RAC1, RAC2, RRAS2, SOS1, SOS2, TRA@, TRD@, VAV2, VAV3, ZAP70
PKCθ Signaling in T Lymphocytes7.670.437AKT2, AKT3, ATM, CALM1, CAMK4, CAMK2D, CAMK2G, CD4, CD28, CD40, CD247, CD3D, CD3E, CD3G, CHP, FCER1G, GRAP2, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ICOS, IKBKB, IL2RB, ITK, ITPR1, ITPR3, LCK, LCP2, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKB2, NFKBIE, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCG1, PLEKHA1, PPP3CC, PRKCQ, RAC1, RAC2, TRA@, TRAT1, TRD@, ZAP70
CD28 Signaling in T Helper Cells7.390.467AKT1, AKT2, AKT3, ARPC4, ARPC5, ATM, CALM1, CAMK4, CARD11, CD4, CD28, CD86, CD247, CD3D, CD3E, CD3G, CDC42, CHP, CTLA4, FCER1G, FYN, GRAP2, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IKBKB, ITK, ITPR1, ITPR3, LCK, LCP2, MALT1, MAPK8, MAPK9, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKB2, NFKBIE, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCG1, PPP3CC, PRKCQ, RAC1, RAC2, TRA@, TRD@, ZAP70
Pancreatic Adenocarcinoma Signaling6.690.471AKT2, AKT3, ATM, BCL2, BCL2L1, BIRC5, CDC42, CDKN2B, E2F2, E2F3, E2F5, EGF, EGFR, ERBB2, HBEGF, HMOX1, JAK1, JAK2, JAK3, KRAS, MAPK1, MAPK8, MAPK9, MDM2, MMP9, NAPEPLD, NFKB1, NFKB2, PA2G4, PDGFC, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLD1, PLD4, PTGS2, RAC1, RAC2, RAD51, RAF1, RALA, RALBP1, RALGDS, SIN3A, SMAD3, SMAD4, STAT1, TFDP1, TGFA, TGFBR1, TP53, VEGFA
NF-κB Activation by Viruses6.280.506AKT2, AKT3, ATM, EIF1, EIF5, EIF1AX, EIF2A, EIF2AK1, EIF2AK2, EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I (includes EG:8, EIF4A1, EIF4A2, EIF4G3, KRAS, MAPK1, NRAS, PAIP1, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PPP1CB, PPP1CC, RAC1, RAC2, RAF1, RPS6, RRAS2, SOS1, SOS2
Molecular Mechanisms of Cancer6.060.371AKT2, AKT3, AP1G1, AP1M2, AP1S2, AP2B1, ATM, CD4, CD28, CD86, CD247, CD3D, CD3E, CD3G, CLTA, CLTCL1, CTLA4, FCER1G, FYN, GRAP2, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, JAK2, LCK, LCP2, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCG1, PPP2R2B, PPP2R5A, PPP2R5C, PTPN22, RAC1, RAC2, TRA@, TRAT1, TRD@, ZAP70
EIF2 Signaling6.010.452AKT2, AKT3, ATM, CCR5, CD4, CR2, CXCR5, EIF2AK2, IKBKAP, IKBKB, ITGA4, ITGA6, ITGAL, ITGB1, ITGB3, ITGB5, KRAS, LCK, MAP3K14, MAPK1, NFKB1, NFKB2, NFKBIE, NRAS, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PRKCD, PRKCH, PRKCQ, PRKCZ, RAC1, RAC2, RAF1, RRAS2, TBP, TNFRSF14
CTLA4 Signaling in Cytotoxic T Lymphocytes5.90.495AKT1, AKT2, AKT3, ANXA1, ATM, BCL2, BCL2L1, CCL3, CCL5, CD163, CD247, CD3D, CD3E, CD3G, CDKN1C, CEBPA, CHP, CREB1, ERCC3, FCGR1A, FKBP5, GTF2H2, GTF2H4, HLTF, HSP90AB1, HSPA8, HSPA9, HSPA14, HSPA1A, IFNG, IKBKB, IL8, IL10, IL1R2, IL1RN, JAK1, JAK2, JAK3, KAT2B, KRAS, MAP3K14, MAPK1, MAPK8, MAPK9, MAPK14, MED1, MMP1 (includes EG:43, NCOA2, NCOA3, NCOR2, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKBIE, NR3C2, NRAS, NRIP1, PBX1, PCK2, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, POLR2B, POLR2E, POLR2G, POLR2H, POLR2I, POLR2J2, POU2F2, PPP3CC, PRKACA, PRKACB, PRL, PTGS2, RAC1, RAC2, RAF1, RRAS2, SLPI, SMAD3, SMAD4, SMARCA4, SOS1, SOS2, SRA1, STAT1, STAT5B, TAF1, TAF3, TAF4, TAF5, TAF11, TAF15, TAF4B, TAF9B, TBP, TGFBR1, TRA@, TSC22D3, UBE2I, VIPR1, YWHAH
Glucocorticoid Receptor Signaling5.670.384ADCY7, ADCY9, AKT1, AKT2, AKT3, APAF1, APH1B, ARHGEF3, ARHGEF7, ARHGEF11, ARHGEF12, ARHGEF18, ATM, ATR, AURKA, BAX, BCL2, BCL2L1, BIRC3, BMPR1A, CAMK2D, CAMK2G, CBL, CCND2, CCND3, CCNE2, CDC42, CDC25A, CDC25B, CDK6, CDKN2B, CDKN2C, CFLAR, CHEK1, CTNNA1, CTNND1, CYCS (includes EG:54, DIABLO, DVL1, E2F2, E2F3, E2F5, FADD, FASLG, FNBP1, FOXO1, FYN, FZD2, FZD5, GAB1, GNA13, GNA15, GNAI3, GNAQ, GNAS, HIPK2, JAK1, JAK2, JAK3, KRAS, LEF1, MAP2K3, MAP2K6, MAPK1, MAPK8, MAPK9, MAPK14, MAX, MDM2, MYC, NAIP, NF1, NFKB1, NFKB2, NFKBIE, NLK, NRAS, PA2G4, PAK2, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PLCB1, PMAIP1, PRKACA, PRKACB, PRKAG2, PRKAR2A, PRKAR2B, PRKCD, PRKCH, PRKCQ, PRKCZ, PRKDC, PSEN1, PTCH1, RABIF, RAC1, RAC2, RAF1, RALA, RALB, RALBP1, RALGDS, RAP2A, RAPGEF1, RASA1, RASGRF2, RASGRP1, RBPJ, RHOA, RHOC, RHOF, RHOG, RHOH, RHOQ, RHOT2, RHOU, RRAS2, SIN3A, SMAD1, SMAD3, SMAD4, SMAD5, SMAD7, SOS1, SOS2, TCF3, TCF4, TFDP1, TGFBR1, TP53
Antigen Presentation Pathway5.570.605CD74, CIITA, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, HLA-G, IFNG, MR1, NLRC5 (includes EG:8, PDIA3, PSMB8, PSMB9, TAP1, TAP2
B Cell Receptor Signaling5.370.433ADCY7, ADCY9, AHNAK, ARHGEF3, ARHGEF7, ARHGEF11, ARHGEF12, ARHGEF18, BLNK, CALM1, CAMK4, CD247, CD3D, CD3E, CD3G, CD79A, CD79B, CHP, CREB1, CREB5, FCER1G, FCGR2B, FCGR2C, FNBP1, FYN, GNA13, GNAQ, GNAS, GNB2L1, GNG2, GNG5, GNG7, GNG11, GRAP2, HDAC4, HDAC9 (includes EG:9, HMOX1, ITGA4, ITGB1, ITK, ITPR1, ITPR3, KRAS, LCK, LCP2, MAPK1, MARCKS, MEF2A (includes EG:4, MEF2C, MEF2D, MYL4, MYL6B, MYL9 (includes EG:10, NAPEPLD, NFAT5, NFATC1, NFATC2, NFATC3, NFKB1, NFKB2, NRAS, PEBP1, PLA2G12A, PLA2G4A, PLCB1, PLCG1, PLD1, PLD4, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PPP3CC, PRKCD, PRKCH, PRKCQ, PRKCZ, RAC1, RAF1, RALA, RALB, RALGDS, RHOA, RHOC, RHOF, RHOG, RHOH, RHOQ, RHOT2, RHOU, RPS6KA3, RRAS2, SOS1, SOS2, TRA@, TRD@, ZAP70
Phospholipase C Signaling5.270.381AKT2, AKT3, ATM, CCNA1, CEBPA, CSF1R, FLT3, FLT3LG, JUP, KIT, KRAS, LEF1, MAP2K3, MAP2K5, MAP2K6, MAPK1, MYC, NFKB1, NFKB2, NRAS, PIK3C3, PIK3C2A, PIK3C2B, PIK3CB, PIK3CG, PIK3R1, PIK3R3, PIM2 (includes EG:11, RAC1, RAC2, RAF1, RARA, RRAS2, RUNX1, SOS1, SOS2, SPI1, STAT5B, TCF3, TCF4, TCF7
Integrin Signaling5.060.415BCL2, CABIN1, CALM1, CAMK4, CD28, CD86, CD247, CD3D, CD3E, CD3G, CHP, CYCS (includes EG:54, FCER1G, HDAC9 (includes EG:9, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, MAP2K5, MAP3K2, MEF2D, NFATC1, PPP3CC, RXRA, SIN3A, TRA@, TRD@