It is observed that female patients have lower survival rate than male patients
after servere burn. What are the gender-specific gene response that might contribute to the survival
difference? We designed this study to address the interaction of gender factor and surival factor
using adult burn patients only.
We used 86 patients and healthy controls, each with two arrays. One array from early stage (0-9days) and the other from middle stage (10-49 days). The head count of patients is shown in the table.
- Interaction effect: genes respond to survival differently in two gender groups
- Addtive effect: genes respond to survival similarly in two gender groups, but their's a difference in signal level
- Gender effect only: genes do not respond to survival, but have gender difference
- Survival effect only: genes respond to survival similarly in two gender groups at similar signal level