Last Upate: 11/10/08


Age-specific gene response to burn

Question


It is observed that pediatric patients have higher chance to survive severe burn than adults. Besides the fundamental difference between children and adults, is there any children specific gene response that helps them survive burn trauma? We designed this analysis to study the interaction of burn factor and age factor. The goal is to identify common gene response to burn regardless of gender, common gene response to gender difference regardless of burn, and most interestly, the age-specific response to burn (interaction between age and burn).

Data


We used 231 patients and healthy controls, each with two arrays. One array from early stage (0-9days) and the other from middle stage (10-49 days). The head count of patients is shown in the table.


Type

Adult (age>=22)

Ped (age<=12)

Grand Total

Burn

110

63

173

Control

28

30

58

Grand Total

138

93

231

 

 

 

 

Result


  • Interaction effect: genes respond to burn differently in two age groups.
  • Gene List

  • Addtive effect: genes respond to burn similarly in two age groups, but their's a difference in signal level.
  • Gene List

  • Burn effect only : genes respond to burn similarly in two age groups at similar signal level.
  • Gene List

  • Age effect only : genes do not respond to burn, but have age group difference.
  • Gene List